Ehancement of Dissolution Rate by Incorporation into a Water Insoluble Polymer, Polycaprolactone

Abstract

This report concerns the use of water insoluble polymer, polycaprolactone, as a carrier to enhance the dissolution rate of two drugs, chlorpromazine and progesterone. Polycaprolactone microspheres containing these drugs were prepared by an emulsion-solvent evaporation technique and dissolution characteristics were compared to pure drug.

Dissolution studies revealed that both chlorpromazine-poly-caprolactone and progesterone–polycaprolactone microspheres exhibited a faster dissolution rate than the pure drugs. Molecular or colloidal dispersion of drugs in the polycaprolactone microshere matrix and the high permeability of polycaprolactone to the drugs and water are possible reasons for the rapid release perties observed.