![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
The particle size of norfloxacin was reduced through the use of an air attrition mill. Not unexpectedly, this treatment also increased the surface area of the drug. Granulations were then prepared from nonmicronized as well as micronized drug. Tablets were compressed from each of these granulations and their physicochemical properties determined. Tablets containing micronized drug showed faster in-vitro dissolution rates and an improvement in bioavailability when tested in Rhesus monkeys.