Dsc Screening for Drug-Drug Interactions in Poly Pharmaceuticals Intended for the Alleviation of the Symptoms of Colds and Flu. II.

S. A. Botha Departments of Pharmaceutics and Pharmaceutical Chemistry and Research, Institute for Industrial Pharmacy, Potchefstroom University for C. H. E., Potchefstroom, 2520, South Africa

A. P. Lötter Departments of Pharmaceutics and Pharmaceutical Chemistry and Research, Institute for Industrial Pharmacy, Potchefstroom University for C. H. E., Potchefstroom, 2520, South Africa

J. L. Du Preez Departments of Pharmaceutics and Pharmaceutical Chemistry and Research, Institute for Industrial Pharmacy, Potchefstroom University for C. H. E., Potchefstroom, 2520, South Africa

Abstract

DSC screening for drug-drug interactions of a polypharmaceutical capsule dosage form containing salicylaminde, ascorbic acid, pyrilamine maleate and phenylephrine hydrochloride was performed. The results show the following:

1. Ascorbic acid is incompatible with salicylamide, pyrilamine maleate and pheynylephrine hydrochloride.

2. Salicylamide is incompatible with ascorbic acid, pyrilamine maleate and phenylephrine hydrochloride.

3. Pyrilamine maleate is incompatible with ascorbic acid, salicylamide and phenylephrine hydrochloride.

4. Phenylephrine hydrochloride is incompatible with salicylamide, pyrilamine maleate and ascorbic acid.

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Dsc Screening for Drug-Drug Interactions in Poly Pharmaceuticals Intended for the Alleviation of the Symptoms of Colds and Flu. II.

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Dsc Screening for Drug-Drug Interactions in Poly Pharmaceuticals Intended for the Alleviation of the Symptoms of Colds and Flu. II.

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