Release Kinetics of Indomethacin from Polymeric Matrices

Abstract

Polymeric matrices containing three different concentrations of indomethacin 1, 2 and 4% preparations were prepared. The release kinetics of indomethacin from matrices followed Higuchi equation. The effective diffusivity of indomethacin (D_m) was 1.32 × 10⁻⁷ +7.4% cm²/sec. The amount released in 24 hours 2 from 10 cm² matrices with three different concentrations of indomethacin, were 12.0, 18.6 and 25.0 mg respectively. These matrices may potentially be developed as a transdermal therapeutic system.