In-vivo Performance of Opthalmic Solutions of Betamethasone and Phenylephrine Hydrochloride in the Eye of Rabbit II. Effect of Methylhydroxy-Ethylcellulose

Abstract

The effect of different concentrations of methyl-hydroxyethylcellulose on the activity of betamethasone (increase of the intraocular pressure, IOP) and phenylephrine hydrochloride (decrease in the IOP and increase pupil diameter) was investigated. The results obtained demonstrate that the parameters of action of betamethasone are influenced by solution viscosity only in the lower range, viz< 4 cP (DO sec⁻¹). The parameters of action of phenylephrine hydrochloride are also dependent on the viscosity of the ophthalmic solution. The data reveal that the dependency of drug action on solution viscosity is reflected by the IOP to an extent greater than that by the papillary response.