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Abstract
To estimate the releasing and pharmacokinetic features of antibiotics used in implantable delivery devices the implants based on stable carrier i.e. polymethylmethacrylate (Septopal) and biodegradable carriers i.e. copolymers of 2-hydroxyethylmethacry-late, N-vinylpyrrolidone and allylic alcohol, mono-carboxylcellulose, collagen, alginic acid and its mixed sodium-calcium salt were studied comparatively. It was shown in_vitro that the implants on the base of polymethylmethacrylate, collagen (especially cross-linked one), alginic acid and monocarboxylcel-lulose had the most pronounced prolongation effect. For the samples using alginic acid and monocarboxyl-cellulose the antibiotic release rate was closely connected with eluent content. The changes of gentamicin levels in the implantation zones were of three-phase character. The drug concentration reached its maximum in phase I, was practically constant in phase II and slowly lowered in phase III. The comparison of the concentration levels and areas under cocentration-time curves showed that the sustained release and pharmacokinetic characteristics of the implants based on cross-linked collagen, alginic acid and monocarbo-xylcellulose were similar to those of polymethylmethacrylate.