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Abstract
The dissolution of 250mg chlorpropamide tablets has been investigated in aqueous methanol co-solvent systems. Dissolution in the mixed solvent systems, despite sink conditions being obtained, was reduced over non-sink conditions in the pure aqueous system due to impaired tablet disintegration. However, tablet disintegration was improved at low methanol volume fractions due to improved wetting and fluid flux into the tablet mass.
A dissolution system was devised using an appropriate amount and order of addition of methanol to the dissolution fluid.