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Abstract
Anhydrous citric acid and sodium bicarbonate were granulated with ethanol in an extruder.
The load on the motor, the dwell time, the fraction above 1.00 mm and below 0.125 mm of unmilled granulation, the geometric mean diameter by weight and the carbon dioxide content of the milled granulation were influenced by all these process variables: powder flow rate, ethanol concentration, screw speed, die restriction and screw configuration. However, the impact of powder flow rate, ethanol concentration and screw speed was partly of an interaction type, except in the case of motorload. As the response variables showed significant interactions, the dependence on the process variables was complex.
The temperature of the extrudate was affected by screw configuration, die plate and ethanol concentration without any interactions.
Regarding the output, this variable was influenced by screw configuration and by an interaction between ethanol concentration and die plate.