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Abstract
The pKa values, solubilities and partition coefficients of a series of O-n-acyl propranolol pro-drugs have been estimated. The direct measurement of solubilities is limited by the instability of the esters and pK values are difficult to estimate by potentiometric titration due to low solubilities. Titrations in a range of aqueous methanolic solutions provide an estimate of the pKa while titration under non-logarithmic conditions, when excess, undissolved base is present in the system, allows the determination of solubility.