Preparation and in Vitro Evaluation of Controlled Release Dosage form of Indomethacin

Abstract

A controlled release oral drug delivery system of Indomethacin was developed using gelatin as the matrix system, which was rigidized with different concentrations of formalin, without using alcohol. The proportion of drug and gelatin as well as the concentration of formalin had the pronounced effect on the Indomethacin release rate and the patterns of which depicted that they correlated with Lang primary requirements for drug release from controlled release dosage forms. All the types of formulations showed release rate patterns that could best be described by First Order Kinetics, indicating that First Order release was mainly operative.