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Drug Development and Industrial Pharmacy Volume 14, 1988 - Issue 4
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Research Article

Simulation of Physiological pH - Time Profile in In Vitro Dissolution Study: Relationship Between Dissolution Rate and Bioavailability of Controlled Release Dosage Form

Sudip K. Das Division of Pharmaceutics Faculty of Engineering & Technology Department of Pharmacy, Jadavpur University, Calcutta, 700 032, India
&
Bijan K. Gupta Division of Pharmaceutics Faculty of Engineering & Technology Department of Pharmacy, Jadavpur University, Calcutta, 700 032, India
Pages 537-544 | Published online: 20 Oct 2008
 
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Abstract

An in vitro batch dissolution method, simulating the in vivo pH-time profile was developed, using the USP XX dissolution apparatus. Significant correlation between in vitro dissolution data and bioavailability of the drug from the controlled release dosage form was obtained.

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