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Drug Development and Industrial Pharmacy Volume 14, 1988 - Issue 12
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Research Article

The Influence of Granulation Process and Surfactants on the Biopharmaceutical Properties of Phenylbutazone Tablets

F. Carli Biopharm. Group, A.F.I., Via Ranzoni 1, 20149, Milano, Italy
,
P. Iamartino Pharm. Technol. Group, A.F.I., Via Ranzoni 1, 20149, Milano, Italy
&
E. Ciranni Signoretti Istituto Superiore di Sanità, Drug Chemistry Laboratory, Viale Regina Elena 299, 00161, Roma, Italy
Pages 1713-1734 | Published online: 20 Oct 2008
 
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Abstract

The influence of granulation process on the biopharmaceutical properties of experimental tablets has been studied, using phenyl butazone as a model substance. Four wet granulation procedures were compared. Moreover, in order to assess the influence of some surfactants, four different formulations were investigated

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