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Abstract
In-vivo evaluation of four different types of aspirin tablets namely effervescent, soluble, buffered and aluminium derivative of aspirin was assessed in six healthy subjects. The bioavailability parameters of the studied aspirin types were calculated. Effervescent aspirin showed the best results, while buffered aspirin showed the worst.
The pharmacokinetic parameters of the six subjects for the different types of aspirin tablets were also computed. Out of all the different types of aspirin tablets studied, effervescent aspirin exhibited the highest absorption rate constant, while aluminium derivative of aspirin showed the lowest absorption rate constant. Sex was found to greatly affect the absorption of aspirin from the different types of tablets studied, where in all cases male subjects gave higher absorption rate constants and greater bioavail ability parameters than females.