In vitro release of betamethasone -17- valereate from various dermatological bases

D. M. Rekkas Dpt. of Pharmaceutical Technology, School of Pharmacy University of Athens. 104 Solonos str., 10680 Athens. Dpt. of Dermatology and Venereology, University of Athens, “A. Sygros” Hospital, Greece

P. P. Dallas Dpt. of Pharmaceutical Technology, School of Pharmacy University of Athens. 104 Solonos str., 10680 Athens. Dpt. of Dermatology and Venereology, University of Athens, “A. Sygros” Hospital, Greece

J. Hatzis Dpt. of Pharmaceutical Technology, School of Pharmacy University of Athens. 104 Solonos str., 10680 Athens. Dpt. of Dermatology and Venereology, University of Athens, “A. Sygros” Hospital, Greece

N. H. Choulis Dpt. of Pharmaceutical Technology, School of Pharmacy University of Athens. 104 Solonos str., 10680 Athens. Dpt. of Dermatology and Venereology, University of Athens, “A. Sygros” Hospital, Greece

Abstract

Betamethasone -17- Valereate release characteristics, from several commercial dermatological bases, were evaluated before and after dilution with several excipients.

It was found that betamethasone releases faster from creams than from ointments. In addition the release of the corticosteroid is affected by the composition of the diluting excipient.

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In vitro release of betamethasone -17- valereate from various dermatological bases

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In vitro release of betamethasone -17- valereate from various dermatological bases

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