A study on in vitro release of five brands of phenytoin capsules, marketed in iran

Abstract

In relation to the new pharmaceutical system in Iran, the in vitro release of five brands of 100 mg phenytoin sodium capsules, namely A,B,C,D & E were determined in distilled water. using three dissolution methods, i.e. Rotating basket, Magnetic basket and Levy beaker method. Also the average amount of phenytoin content of each brand was measured.

The results showed that although the dissolution rate of each product is different by each method, but the pattern of drug release is more or less similar.

The dissolution time for products C and D is much longer than those of products A,B & C with all methods, but the dissolution behaviour of capsules C & D is not equivalent to those of standard “slow release” phenytoin capsules. The release pattern of products A & E are similar to those of standard “fast release” phenytoin capsules. The dissolution of product B is poor and not acceptable.