Variations in Lactose NF from two Different sources and their Influence on Tablet Properties

Abstract

Samples of Lactose NF obtained from one supplier in the UK and one in the USA were examined in terms of their compaction properties. The materials were studied in a model formulation and also in a development formulation. Differences in properties between the samples were shown to depend principally on the particle size, size distribution and specific surface area. The source of lactose can have significant deleterious effects on a multicomponent formulation even when lactose is not the major component.