Comparison of the Bioavailability of oral and Rectal forms of Diphenylhydantoin Sodium

Abstract

The bioavailabilities of single 100-mg oral and rectal doses of diphenylhydantoin sodium were studied in five healthy volunteers. The rectal form used was prepared at laboratory conditions and the oral form was a commercial preparation. Blood samples were analysed over a 72-hr period. Evaluation of the AUC, t_max and C_max values have shown that the total absorption after the two routes of administration was the same while the C_max and t_max differed.