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Research Article

Elaboration and Characterization of the Diazepam-Polyethyleneglycol 6000 Solid Dispersions

, , , &
Pages 2283-2301 | Published online: 20 Oct 2008
 

Abstract

Diazepam-polyethyleneglycol 6000 solid dispersions systems were prepared by melting and solvent methods. These dispersions were characterized using D.T.A., X-Ray diffraction and microscopy. The phase diagram has shown that this system is characterized as a simple eutectic mixture with a eutectic composition of 87% diazepam and 13% P.E.G. 6000. Solubility studies showed a linear increase in drug solubility with the increase of PE.G. 6000 concentration.

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