Abstract
Tablets of aspirin, ascorbic acid and pyridoxine hydrochloride were prepared by direct compression, using bone powder or Emcompress, respectively as direct compression fillers. Tablet properties such as mean weight, thickness, breaking strength and friability were monitored before and after storage for 30 days under specified temperature and relative humidity conditions. The tablet properties were apparently unaffected by the conditions of storage, while release parameters were, however, modified. In vitro dissolution rate constant, was found to exhibit good correlation with the dissolution efficiency.