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Research Article

The Determination of Water in Freeze Dried Pharmaceutical Products by Performing the Karl Fischer Titration in the Glass Container Itself

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Pages 1465-1472 | Published online: 20 Oct 2008
 

Abstract

A micro device is described by which it is possible to perform the Karl Fischer titration in the ampoule or vial containing a freeze dried pharmaceutical product. Using this device, it is not necessary to transfer the product from the original container into another vessel which means less manipulations to be performed and a lower risk to changes in moisture content during the analytical procedure.

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