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Abstract
The effect of tablet aging on the dissolution efficiency of three “super disintegrants”, sodium starch glycolate, crospovidone, and croscarmellose sodium, was investigated utilizing directly compressed tablets. Lactose, dicalcium phosphate dihydrate, and sorbitol, alone or in combination, provided varying degrees of solubility and hygroscopicity to the direct compression tablet formulations. The results indicate that aging did not decrease the effectiveness of the super disintegrants in promoting invitro dissolution. The composite solubility and hygroscopicity of the tablets did not adversely influence the aging characteristics of the super disintegrants. Super disintegrants that complied with the same compendial specifications but were obtained from different sources behaved similarly in promoting tablet dissolution after storage.