Simple Prediction of Stability Constants for Inclusion Complexes of β-Cyclodextrin with various Drug Molecules Using β-Cyclodextrin Bonded Phases(Cyclobond® I Column)

Mingxin Wang Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo, 142, Japan; China National Institute of Pharmaceutical R&D, P.O. Box 948, Beijing, 100083, China

Haruhisa Ueda Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo, 142, Japan

Tsuneji Nagai Faculty of Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo, 142, Japan

Abstract

The stability constants(K_c) for inclusion complexes of cyclodextrin with sulfonamides, sulfonylureas and p-aminobenzoic acid esters were investigated by high performance liquid chromatography (HPLC) using the cyclodextrin bonded phase. The retention time(R_t) of these drugs on a Cyclobond® I column showed a good relationship to K, values obtained by the solubility method and/or conventional HPLC method. The advantages of this method were that the K, values could be rapidly predicted by a simple procedure using a minimum quantity of the drugs.

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Simple Prediction of Stability Constants for Inclusion Complexes of β-Cyclodextrin with various Drug Molecules Using β-Cyclodextrin Bonded Phases(Cyclobond® I Column)

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Simple Prediction of Stability Constants for Inclusion Complexes of β-Cyclodextrin with various Drug Molecules Using β-Cyclodextrin Bonded Phases(Cyclobond® I Column)

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