Physical Aspects of Wet Granulation IV – Effect of Kneadign time on Dissolution Rates and Tablet Properties

K. D. Brtel Merrell Dow Research Institute Clincinnati, OH, 45215

M. A. Zoglio Merrell Dow Research Institue Institute Cincinnati, OH, 45215

W. A. Ritschel College of Pharmacy, University of Cinicinnati Meidal Center Cinicnnati, OH, 45267

J. T. Carstensen School of Pharmacy, Univeristiy of Wisconsion Madison, WI, 53706

Abstract

The phsical properties of sucrose-lactoes-strach granulations containing a water soluble drug are characterized, and the relationship between granulaion kneading time and each of the these properties is examined. In addition, the effect of granulation kneading time on the properties of tablets prepared from the granules is examined.

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Physical Aspects of Wet Granulation IV – Effect of Kneadign time on Dissolution Rates and Tablet Properties

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Physical Aspects of Wet Granulation IV – Effect of Kneadign time on Dissolution Rates and Tablet Properties

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