Effect of Crospovidone on the Wet Granulation aspectc of Acetaminophen

Abstract

The effect of crospovidone on the characteristics of wet granulated acetaminophen was investigated. Power blends of acetaminophen and crospovidone were wet granulated using hydroxypropyl methlcellulose as the binder and water as the granulating liquid. The sieve analysis data showed that as the level of crospovidone in the powder blend increased, there was an increase in the ammount of fines in the particle distribution of the dried granulations. The bulk densities of fromulae containing a higher level of crospovidone were generally lower although no clear trend was seen for the tap denstiy values. Interferences in the hydratin of hydroxypropyl methylecellulose, and increase in the total surface ara were considered as two possible mechanisms for the effect foc crospolvidone. The results of this study indicate that an interaction of both mechanisms may be responsible for the effect of crospovidone on the chracteristics of wet granulated acetaminophen.