Some Pharmaceutical Studies on Sustained Release Coprbcipitates of Ampicillin Trihydrat with Acrylic Resin (Eudragit)(R)-RS)

Abstract

Coprecipitates of Ampicillin trihy drate with acrylic resin (Eudragit(R)-RS) were prepared. Comparative dissolution rate studies of the coprecipittes and pure ampicillin showed that, the coprecipitates slowed down the release rate of t h e drug. Bioavailability studies in human subjects using urinary excretion method indicated a lower rate and extent of drug absorption from the tablet for-ulation containing coprecipitated drug, as compared to the tablets formulated from the pure drug. 50th the in - vitro and the in - vitroresults suggest that the embeddment of ampicillin trihydratein Eudragit-RS by the coprecipitation technique, show agreat promise in sustaining the drug's release in a matrix controlled drug delivery system.