The Physico-Chemical Effect of Coacervation Conditions on the Diffusional Properties and Surface Morphology of Biodegradable Microcapsules

Abstract

Microcapsules containing kaolin and hydrocortisone 21- acetate (HCAC) were produced through controlled coacervation of a biodegradable block copolymer of d-tartaric acid and 1, 10-octanediol, under Plait and non-Plait compositions. Diffusional studies indicated that the permeability of Plait microcapsules was at least 40% greater than non-Plait microcapsules at the same polymer to core ratio. Scanning electron photomicrographs of the various microcapsules suggested surface morphologic differences among microcapsules produced under Plait and non-Plait solvent conditions.