![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
The water-insoluble antileprotic drug clofazimine, was solubilized by solid dispersion in polyvinylmetnyl ether/maleic anhydride copolymer. Dissolution tests in acidic, neutral and alkaline media showed that the dispersion (coevaporate) exhibited superior dissolution characteristics, compared to the pure compound or the physical admixtures of the drug and the polymer. Dissolution tests also revealed that the release of clofazimine from the coevaporate in the test solutions, was of zeroorder and that rate and extent of release increased with polymer concentration in the coevaporate. However, the lagtime prior to drug release also increased with polymer concentration. The rate of release was enhanced in the alkaline medium.
UV-visible and infra red spectra and also thin layer and high performance liquid chromatograms taken after the coevaporate preparation and several times during storage, indicated no apparent physicochemical change in clofazimine in the coevaporate. Accelerated stability studies of the coevaporate during a 12-week period at 25°, 37°, and 50°C indicated that negligible amount of clofazimine had degraded during the storage period. Kinetically the apparent loss of clofazimine in the coevaporate is indistinguishable between zeroorder and firstorder.