Sustained release nifedipine formulations: Moment, Modelling and Simulation as pharmacokinetic analysis approach

Abstract

The bioequivalence of three sustained release nifedipine formulations designed in this laboratory, was assayed in rabbits by comparing their plasma time profiles to a reference (Adalat^R retard).

The analysis of data was performed by using the statistical moments as a measure of drug release. Results show a slowler absorption rate in the experimental formulations than in Adalat^R retard, and not differences in the absorption extent.

The composed one-compartment model, described for humans, showed to be also succesfull for rabbits.