Effect of a Lubricant on Wear Rate of Tablets

Abstract

The rate of wear and hardness of tablets of Emcompress and sodium chloride compressed at various applied pressures in a lubricated and an unlubricated die are compared. The effect of applied pressure and concentration of magnesium stearate blended with several direct compression excipients on the wear rate constant, hardness and tensile strength of a tablet is reported. The data allow a comparison of the methods used to express the mechanical strength of tablets.