Natural Polymer Hydrophilic Matrix: Influencing Drug Release Factors

S. Rizk Laboratoire de Pharmacie galénique, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, Université de Montpellier I Avenue Charles Flahault, 34060, Montpellier, Cedex, France

C. Duru Laboratoire de Pharmacie galénique, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, Université de Montpellier I Avenue Charles Flahault, 34060, Montpellier, Cedex, France

D. Gaudy Laboratoire de Pharmacie galénique, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, Université de Montpellier I Avenue Charles Flahault, 34060, Montpellier, Cedex, France

M. Jacob Laboratoire de Pharmacie galénique, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, Université de Montpellier I Avenue Charles Flahault, 34060, Montpellier, Cedex, France

P. Colombo Dipartimento Farmaceutico, University of Parma Via delle Scienze, 43100, Parma, Italy

G. Massimo Dipartimento Farmaceutico, University of Parma Via delle Scienze, 43100, Parma, Italy

Abstract

In porous hydrophilic polymeric systems, two phenomena control the release of drugs: the water uptake and polymer swelling.

Directly compressed hydrophilic matrices were prepared with scleroglucan as gelling agent. A principal components analysis enables the authors to study the correlation between the above phenomena and the dissolution behavior in order to interpret the effect of polymer concentration, excipient solubility and compression force on the drug release.

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Natural Polymer Hydrophilic Matrix: Influencing Drug Release Factors

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Natural Polymer Hydrophilic Matrix: Influencing Drug Release Factors

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