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Abstract
The introduction of new sustances that can be used as excipient in controlled release formulations constitutes a relevant step in obtaining simple, reliable and accurate methods which makes it possible to reproduce the controlled release of drugs.
Therefore, the aim of this work is to study the influence of different technological variables on the modulation of the release of the active principle compressed with a new excipient to formulate matrix tablets. A Poliamyde 12 was used as the rate-controlling polymer in controlled-release tablet formulation. Different techniques of multivariate analysis have been applied to the release characterization of matrix tablets studied.