Bioavailability of Directly-Compressed Indomethacin, Indomethacin Sodium and Indomethacin Meglumine Tablets

Abstract

The prepared film-coated directly-compressed indo-methacin, indomethacin sodium and indomethacin meglumine tablets, plain indomethacin in hard gelatin capsule and the commercial product “Indocid” capsules, were subjected to bioavailability testing in six healthy volunteers. Each treatment was given as single oral dose of 50 mg. The excreted drug was estimated in urine at 1, 2, 4, 6, 8, 10, 12 and 24 hours post-drug administration. The cumulative amount excreted, percent dose excreted, ^Qmax' ^tmax' ^Kel' ^t½el and relative bioavailability, to plain drug, were determined. The obtained results revealed that directly-compressed film-coated indomethacin meglumine tablets had the best relative bioavailability than the other treatments.