In-Vitro Release Kinetics of Salbutamolsulphate Microcapsules Coated with Both Eudragit Rs 100 and Eudragit RL 100

Abstract

Sabutamolsulphate, a bronchodialatory drug for Asthma is encapsulated by Eudragit RS 100 and Eudragit RL 100 of varying ratios (1:1, 3:1, 1:3) using Emulsion-Solvent-Evaporation method. The experimental data obtained from the in-vitro dissolution study have been computed in the light of different kinetic models like Zero Ordr, Higuchi Matrix, First Order, Baker-Lonsdale. An extensive programming in BASIC is performed to determine the co-relation coefficient and slope for each of the functions. The diffusivity rate constant (K_BL) and diffusion coefficient (Da) have been evaluated with the help of Baker-Lonsdale Model.