Analysis of Content Uniformity Data of Tablets with two Active Ingredients

Abstract

A method based on scatter plots of content uniformity data of tablets containing two active ingredients was utilized to gauge the degree of segregation in the finished product. The difference of semi-axes of the tolerance ellipse imposed on the content uniformity data and the covariance of data were found to be useful in estimating degree of segregation. Direct compression formula of a specific case was found to have slightly more segregation than a wet granulated product.