Preparation and Characterization of Ranitidine-HC1 Crystals

Abstract

Four crystalline and one noncrystalline form of RANITIDINE-HC1 were prepared and characterized by means of X-Ray powder diffraction, Thermal analysis (D.T.A. & T.G.A.), Polarising microscopy, Scanning electron microscopy, Infra red spectrophotometry and Ultra violet spectrophotometry. All the four crystalline forms were solvates or pseudopolymorphs. Stability determination of various forms under different conditions exhibited FORM II as most stable and all other forms convert to FORM II during storage. Humidity, Temperature and Compression force affected the polymorphic stability of various forms. Transition temperatures of different forms were determined using Equilibrium solubility method.