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Abstract
The USP XXII specifies that the disintegration time for nitrofurantoin tablets must be not less than 30 minutes, not less than 25% of the drug is dissolved in 60 minutes and not less than 85% is dissolved in 120 minutes. These specifications were done to minimize the side effects and to achieve a proper bioavailability for the drug.
On testing the market tablet preparation (Furadantin), it was found that it does not fit to the [JSP specifications, Nine nitrofurantoin tablet formulations were then tried and each was studied for disintegration time and % dissolution in the first and second hours. The best formula was found to be consisted of adding 2% of collodion in 40% of the starting granules, coated with 4% CAP and adding another 2% of collodion to the remaining 60% of the granules.