![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
The influence of 2-hydroxypropyl-β-cyclodextrin (HPβCD) on the permeability of hydrocortisone through semi-permeable cellophane membrane and hairless mouse skin was investigated. When the hydrocortisone concentration was kept constant and the HPβCD concentration in an aqueous vehicle was gradually increased the flux through the semi-permeable membrane was increased until all hydrocortisone had dissolved, after that the flux decreased with increasing HPβCD concentration. A maximum flux was obtained when just enough HPβCD was used to dissolve all the drug in the aqueous vehicle.