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Abstract
Sustained-release tablets containing oxazepam were prepared and dissolution profiles were investigated. The total dose of oxazepam is constituted of initial and maintenance dosage. A method for the preparation of hydrophilic matrix tablets is presented. The study of the dissolution rate of these preparations in artificial gastric (in the first two hours) and enteric juices (in the following ten hours) was experimented. No significant differences in oxazepam release rate were found between the formulations containing lactose, zinc sulfate, calcium sulfate or calcium phosphate added intragranularly to the maintenance dosage. The dissolutions studies of oxazepam preparations demonstrated differences in drug release properties depending on the content of extragranular croscarmellose sodium.