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Abstract
Multilamellar liposome vescicles containing ibuprofen were successfully prepared by hydrating the lipids in the presence of organic solvent. The effects of varying the ratio of lipid to drug; the filter size; and the stirring period during hydration of the dried lipids layer were evaluated. Liposomes sample prepared by using a ratio of 3 lipid: 1 drug gave the highest entrapment efficiency of the drug and released all the drug over 12 hours of testing dissolution. Also the dissolution data showed that the drug release from large liposomes (5.0 μm) was 65.7% after 12 hours; 62.6% from medium size (0.8 pm) and 46.6% from small size liposomes (0.22 μm). Additionally, the increase of the stirring period during hydration of the dried lipid layer with the aqueous phase increased the release of the drug from the liposomes.