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Abstract
A comparative study of two methods of dissolution (Simoons Apparatus and USP XXII Apparatus II) has been accomplished using sustained-release 50 mg anhydrous theophylline tablets. Sovic® 374 MB, Eudragit® RL PM, Aquacoat®, Methocel® K-15M, and Cutina® HR were some of the excipients used to elaborate inert, hydrophilic, and lipidic matrices. Theophylline release was prolonged in all cases, except when Aquacoat was used as matrix constituent. Simoons device was found to be more accurate for inert matrix tablets, whereas USP apparatus was advantageous for hydrophilic and lipidic matrix. ANOVA showed significant differences among all the factors analyzed. The drug release kinetics was adjusted better to Higuchi's kinetic model than to the Noyes-whitney or Weibull models, from 10% to 70% release.