Characterization of Glyburide-Polyethylene Glycol Solid Dispersions

Abstract

Glyburide (GLY) is an oral hypoglycemic agent that is poorly water soluble. Solid dispersions of polyethylene glycol (PEG) 4000, PEG 6000, and mixtures of PEG 4000 and 6000, were prepared by the melt-and-solvent method. Phase analysis was performed by x-ray powder diffraction and differential scanning calorimetry (DSC) to study the nature of interaction in the solid state. The x-ray diffraction pattern indicated that the dispersion had an amorphous nature as compared to the crystalline drug. The melting endothermal point of GLY was eliminated in the dispersions of DSC thermograms. The results showed that there was no chemical interaction between the drug and the polymer. Also, formation of solid solution is apparent from the DSC thermograms.