Studies on Gel Tears

Abstract

Artificial tear substitutes, namely gel tears, were formulated and evaluated in the treatment of keratoconjunctivitis sicca. A preservative efficacy test was performed to evaluate the most suitable preservative for the gel tears. The gel tears were subjected to varying stability conditions and assessed for various parameters, viz pH, viscosity, clarity, extrudability, and sterility. Eye irritation studies were performed on albino rabbits using the Draize technique. Clinical trials were conducted on normal volunteers and volunteers with mild to moderate conditions of keratoconjunctivitis sicca.