Vitamin C Spray Drying: Study of the Thermal Constraint

Abstract

Temperature variation in the spray drying method has no effect on the ascorbic acid molecule. No chemical interaction between the colloidal silica and the ascorbic acid could be determined, but a physicochemical interaction “absorption” was determined. Colloidal silica improved the final yield of spray drying in proportion to its concentration. No polymorphic forms could be determined in the spray-dried ascorbic acid. Drug release from the ascorbic acid spray dried was found to be dependent on the Aerosil content: highest release rates were obtained with Aerosil.