Effervescent Tablets of Ascorbic Acid. I. Physical Study of the Possible components to Be Used

Abstract

The stability of ascorbic acid effervescent tablets is substantially affected by moisture. Therefore the choice of suitable excipients is a very important step in the formulation study of this type of tablets. This work reviews the most common excipients used in effervescent preparations. They are characterized by microscopical observation and determination of particle size distribution, density, moisture, hygroscopicity, and electrostatics. Hygroscopicity is the most important property when choosing an excipient for an effervescent preparation. Therefore, two different methods for its determination have been used.