Investigation on a New Modified USP Xanthan with Tablet-Disintegrating Properties

Abstract

The disintegrating efficiency of a new USP xanthan derivative, Xanthan SM® was evaluated. First, the physical parameters of Xanthan SM were compared to USP xanthan, a highly gelihing excipient, and AcDiSol® a powerful and well-known disintegrant. Tablets were prepared by direct compression using acetylsalicylic acid as the drug. The effective amount of each disintegrant was determined. The influence on compression behavior, disintegration time, and drug dissolution rate was considered. This study makes it clear that the characteristics of Xanthan SM are totally difflerent from those of USP xanthan. Xanthan SM proved to be as good as AcDiSol