A New Method to Evaluate the Elastic Behavior of Tablets During Compression

Abstract

A new method to evaluate elastic/plastic behavior of tablets from tablet compression force-time data is presented. Tablets were compressed in an instrumented eccentric single-punch tablet machine. Equations for the calculation of relative elasticity were derived for both upper and lower punch forces. The experimental work was based on a 3² design having binder solution amount and atomizing air pressure as independent variables. Multilinear stepwise regression analysis was applied in studying the effects of granulation variables. It was concluded that the relative elasticity of tablets is dependent on binder solution amount. Furthermore, this study showed that the relative elasticity parameters can be useful in quantification of elastic behavior of tablets