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Abstract
The effects of oleic acid and lauric acid in a mixture of fatty alcohol and propylene glycol (FAPG base) on the percutaneous absorption of fluocinolone acetonide (FA) were investigated by using nude mouse skin and synthetic membrane in vitro. me mixture of 0.9% sodium chloride and methanol (91) was used as the receptor phase for the diffusion study. The concentration of FA in the receptor phase was determined by HPLC. fie optimal formulation of the FAPG base was obtained with the addition of 5% lauric acid