comparative Evaluation of Targeting Efficiency of Charged and Neutral Liposomes of 5-Fluorouracil

Abstract

Liposomes were prepared from egg lecithin by the modified ether injection technique using stearylamine and dicetyl phosphate as the charge-inducing agents. Comparative evaluations of charged and neutral liposomes for drug entrapment, size distribution, in vitro drug release, and in vivo drug targeting were made. The charged liposomes were larger in size and showed better drug entrapment efficiency than the neutral liposomes. However, no difference in the pattern of in vitro drug release was observed. Charged liposomes were found entrapped more in the organs of the reticulo-endothelial system than the neutral liposomes.