Percutaneous Absorption of LHRH Through Porcine Skin: Effect of N-Methyl 2-Pyrrolidone and Isopropyl Myristate

Abstract

The effect of penetration enhancer (PE) on the in vitro permeability of luteinizing hormone-releasing hormone (LHRH) through porcine epidermis was investigated. The permeability coefficient of LHRH significantly increased (p < 0.05) through PE-(e.g., n-methyl 2-pyrrolidone [NMP], and isopropyl myristate [IPM]) treated epidermis in comparison to the control (without PE-pretreated epidermis). The higher permeability coefficient was observed with NMP followed by IPM. This shows that PE such as NMP and IPM can enhance the percutaneous absorption of peptides such as LHRH.