Etodolac and Solid Dispersion with P-Cyclodextrin

J. Milić-Aškrabić Faculty of Pharmacy, Pharmaceutical Technology Department, Belgrade University, V. Stepe 450, 11221, Belgrade, Yugoslavia

D. S. Rajić Military Technical Institute, Chemical Department, Kataniceva 15, 11000, Belgrade, Yugoslavia

Lj. Tasić Faculty of Pharmacy, Pharmaceutical Technology Department, Belgrade University, V. Stepe 450, 11221, Belgrade, Yugoslavia

S. Djurić Faculty of Science, Belgrade University, Djušina 7, 11000, Belgrade, Yugoslavia

P. Kása Department of Pharmaceutical Technology, Albert-Szent-Gyorgy Medical University, Szeged, Hungary

K. Pintye-hódi Department of Pharmaceutical Technology, Albert-Szent-Gyorgy Medical University, Szeged, Hungary

Abstract

Etodolac/β-cyclodextrin (Eto/β-CD) dispersions were prepared with a view to study the influence of β-CD on the solubility and dissolution rate of this poorly soluble drug. Two systems were used: physicai mixture of Eto/β-CD and kneading solid dispersion of Eto/β-CD. Physical characterization of the prepared systems was carried out by scanning electron microscopy (SEM), differential scanning calorimetric (DSC), x-ray, and IR studies. The solubility and dissolution rate of Eto were increased with β-CD physical mixture as well us with Eto/β-CD kneading solid dispersion. However, enhancement was not statistically different among various cyclodextrin dispersions.

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Etodolac and Solid Dispersion with P-Cyclodextrin

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Etodolac and Solid Dispersion with P-Cyclodextrin

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